Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration

2019282 citationsJournal Articlebronze Open Access

Authors

Qin Fan · Shanghai Jiao Tong University

Rong Tao · Shanghai Jiao Tong University

Hang Zhang · Shanghai Jiao Tong University

Hongyang Xie · Shanghai Jiao Tong University

Lin Lu · Shanghai Jiao Tong University

Ting Wang · Shanghai Jiao Tong University

Min Su ·

Abstract

Our results reveal a crucial role of Dectin-1 in the process of mouse myocardial IR injury and provide a new, clinically significant therapeutic target.

Topics & Keywords

Cardiac Fibrosis and Remodeling Signaling Pathways in Disease Neutrophil, Myeloperoxidase and Oxidative Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 139, Issue 5, pp. 663-678

DOI: 10.1161/circulationaha.118.036044

Field-Weighted Citation Impact: 13.68