Flavopiridol as cyclin dependent kinase (CDK) inhibitor: a review

201849 citationsReview

Authors

Aakash Deep · Chaudhary Devi Lal University

Rakesh Kumar Marwaha · Maharshi Dayanand University

Minakshi Gupta Marwaha · Indian Institute of Management Rohtak

Jyoti Jyoti · Indian Institute of Management Rohtak

Rimmy Nandal · Chaudhary Devi Lal University

Arun Kumar Sharma · Amity University

Abstract

Flavopiridol (alvocidib) is a synthetic flavonoid based on the extract from an Indian plant developed for potential treatment of cancer whose first clinical trials were initiated in 1994 as a frontline combination therapy for leukaemia.

Topics & Keywords

Advanced Breast Cancer Therapies Cancer-related Molecular Pathways Chronic Lymphocytic Leukemia Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New Journal of Chemistry

Volume 42, Issue 23, pp. 18500-18507

DOI: 10.1039/c8nj04306j

Field-Weighted Citation Impact: 2.91