Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis

201852 citationsReviewgold Open Access

Authors

Mingyue Rao · Macau University of Science and Technology

Chenlin Gao · Macau University of Science and Technology

Betty Yuen Kwan Law · Macau University of Science and Technology

Yong Xu · Macau University of Science and Technology

Abstract

Metformin appears to improve the tumor response to radiotherapy in patients with cancer and DM and partly yield survival benefits. Despite the apparent advantages provided by metformin treatment on 2y-OS and 5y-OS, these retrospective data are at risk of bias and should be interpreted with caution.

Topics & Keywords

Metabolism, Diabetes, and Cancer Cancer-related Molecular Pathways PI3K/AKT/mTOR signaling in cancer

Publication Details

Published in: Cancer Management and Research

Volume Volume 10, pp. 4881-4890

DOI: 10.2147/cmar.s174535

Field-Weighted Citation Impact: 1.96

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Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis

Authors

Abstract

Topics & Keywords

Publication Details