Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair

2019366 citationsJournal Article

Authors

Tony Tang · National Yang Ming Chiao Tung University

Hung-Chih Chen · HTC (Taiwan)

Chen-Yun Chen · HTC (Taiwan)

Christopher Yen · HTC (Taiwan)

Chen‐Ju Lin · HTC (Taiwan)

Ray Putra Prajnamitra · HTC (Taiwan)

Li-Lun Chen · HTC (Taiwan)

Abstract

Gut microbiota-derived SCFAs play an important role in maintaining host immune composition and repair capacity after MI. This suggests that manipulation of these elements may provide opportunities to modulate pathological outcome after MI and indeed human health and disease as a whole.

Topics & Keywords

Gut microbiota and health Clostridium difficile and Clostridium perfringens research Frailty in Older Adults

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 139, Issue 5, pp. 647-659

DOI: 10.1161/circulationaha.118.035235

Field-Weighted Citation Impact: 14.18