Levodopa‐induced dyskinesia in Parkinson disease: Sleep matters

201830 citationsJournal Articlebronze Open Access

Authors

Ninfa Amato · Laboratory for Biomedical Neurosciences

Mauro Manconi · Laboratory for Biomedical Neurosciences

Jens Carsten Möller · Philipps University of Marburg

Simone Sarasso · University of Milan

Paolo Stanzione · University of Rome Tor Vergata

Claudio Staedler · Laboratory for Biomedical Neurosciences

Alain Kaelin‐Lang

Abstract

Our data demonstrate a strong pathophysiological association between sleep and PD. Given that SWA may be a surrogate for synaptic strength, our data suggest that DYS patients do not have adequate synaptic downscaling. Further analysis is needed to determine the effect of drugs that can enhance cortical SWA in LID. Ann Neurol 2018;84:905-917.

Topics & Keywords

Sleep and Wakefulness Research Parkinson's Disease Mechanisms and Treatments Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 84, Issue 6, pp. 905-917

DOI: 10.1002/ana.25360

Field-Weighted Citation Impact: 1.14