C5a receptor 1<sup>−/−</sup> mice are protected from the development of IgE‐mediated experimental food allergy

201820 citationsJournal Article

Authors

Anna Kordowski · University of Lübeck

Anna T. Reinicke · University of Lübeck

David Wu · Cincinnati Children's Hospital Medical Center

Zane Orinska · Research Center Borstel - Leibniz Lung Center

Philipp M. Hagemann · Research Center Borstel - Leibniz Lung Center

Markus Huber‐Lang · University Hospital Ulm

Jee‐Boong Lee

Abstract

Our findings identify C5aR1 activation as an important driver of IgE-mediated food allergy through regulation of allergen-specific IgE production, FcεR1-mediated MC degranulation, and histamine-driven effector functions preferentially in male mice.

Topics & Keywords

Mast cells and histamine Food Allergy and Anaphylaxis Research Allergic Rhinitis and Sensitization

Publication Details

Published in: Allergy

Volume 74, Issue 4, pp. 767-779

DOI: 10.1111/all.13637

Field-Weighted Citation Impact: 0.77

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C5a receptor 1<sup>−/−</sup> mice are protected from the development of IgE‐mediated experimental food allergy

Authors

Abstract

Topics & Keywords

Publication Details