P16INK4a expression in patients with penile cancer

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Authors

Vicenilma de Andrade Martins · Universidade Federal do Maranhão

Jaqueline Diniz Pinho · Universidade Federal do Pará

Antonio Augusto Lima Teixeira Júnior · Universidade Federal do Maranhão

Leudivan Ribeiro Nogueira · Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão

Fábio França Silva · Universidade Estadual do Ceará

Victor Eduardo Maulen

André Salim Khayat ·

Abstract

Our study, using fresh tissue samples, showed the highest incidence of HPV compared to that observed in the literature. Expression of the p16INK4a protein was significantly associated with the presence of HR-HPV and this expression may serve as a marker for the presence of the virus. The p16INK4a protein was not associated with the histological prognostic parameters, with the exception of tumor subtype, nor with patient survival. In the results, we showed that the objective of the present study was reached.

Topics & Keywords

Genital Health and Disease Ethics and Legal Issues in Pediatric Healthcare Urologic and reproductive health conditions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 13, Issue 10, pp. e0205350-e0205350

DOI: 10.1371/journal.pone.0205350

Field-Weighted Citation Impact: 3.55