Neoantigenic Potential of Complex Chromosomal Rearrangements in Mesothelioma

2018127 citationsJournal Articlehybrid Open Access

Authors

Aaron S. Mansfield · WinnMed

Tobias Peikert · Mayo Clinic

James B. Smadbeck · Mayo Clinic

Julia Udell

Enrique Garcia-Rivera · Nference (United States)

Laura R. Elsbernd · Mayo Clinic

Courtney L. Erskine · Mayo Clinic

Abstract

Our findings represent the discovery of potential neoantigen expression driven by structural chromosomal rearrangements. These results may have implications for the development of novel immunotherapeutic strategies and the selection of patients to receive immunotherapies.

Topics & Keywords

Occupational and environmental lung diseases Cancer Immunotherapy and Biomarkers Genetic factors in colorectal cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Thoracic Oncology

Volume 14, Issue 2, pp. 276-287

DOI: 10.1016/j.jtho.2018.10.001

Field-Weighted Citation Impact: 11.91