Front Cover: Photoacoustic microscopy for evaluating combretastatin A4 phosphate induced vascular disruption in orthotopic glioma (J. Biophotonics 10/2018)

Optical resolution photoacoustic microscopy (OR‐PAM) imaging system is exploited to evaluate the vascular disruptive effect of Combretastatin A4 Phosphate (CA4P), a solid tumor drug, on a murine orthotopic glioma with intact skull. Hemodynamic changes in tumor vasculature are in agreement with the well documented shutdown and recovery associated CA4P administration. High resolution vasculature images obtained using OR‐PAM enable mapping of each individual blood vessel's response to the treatment. Further details can be found in the article by Renzhe Bi, Ghayathri Balasundaram, Seungwan Jeon, et al. ( e201700327 ) image