Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

2018161 citationsJournal Articlegreen Open Access

Authors

Keertan Dheda · University of Cape Town

Laura Lenders · University of Cape Town

Gesham Magombedze · National Center for Infectious Diseases

Shashikant Srivastava · National Center for Infectious Diseases

Prithvi Raj · The University of Texas Southwestern Medical Center

Erland Arning · Baylor University Medical Center

Paula Ashcraft

Abstract

These data inform interventional strategies relevant to drug delivery, dosing, and diagnostics to prevent the development of acquired resistance. The role of high intracavitary penetration as a biomarker of antibiotic efficacy, when assessing new regimens, requires clarification.

Topics & Keywords

Tuberculosis Research and Epidemiology Infectious Diseases and Tuberculosis Diagnosis and treatment of tuberculosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 198, Issue 9, pp. 1208-1219

DOI: 10.1164/rccm.201711-2333oc

Field-Weighted Citation Impact: 10.98