Serum Neurofilament light correlates with CADASIL disease severity and survival

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Authors

Gido Gravesteijn · Leiden University Medical Center

Julie W. Rutten · Leiden University Medical Center

Inge M.W. Verberk · Amsterdam Neuroscience

Stefan Böhringer · Leiden University Medical Center

Michael Liem · Lange Land Ziekenhuis

Jeroen van der Grond · Leiden University Medical Center

Annemieke Aartsma‐Rus

Abstract

Serum NfL levels correlate with disease severity, disease progression and 17-year survival in CADASIL patients. Serum NfL is a promising biomarker to monitor and predict disease course in CADASIL, as well as potentially assessing therapeutic response in future clinical trials.

Topics & Keywords

Cerebrovascular and genetic disorders Moyamoya disease diagnosis and treatment Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Clinical and Translational Neurology

Volume 6, Issue 1, pp. 46-56

DOI: 10.1002/acn3.678

Field-Weighted Citation Impact: 2.38