miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC

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Authors

Xiaoyuan Wang · Harbin Medical University

Qingwei Meng · Third Affiliated Hospital of Harbin Medical University

Wenbo Qiao · Third Affiliated Hospital of Harbin Medical University

Ruishuang Ma · Harbin Medical University

Weiwei Ju · Eastern Liaoning University

Jing Hu · Third Affiliated Hospital of Harbin Medical University

Hailing Lu

Abstract

This study elucidates an important role of miR-181b in the regulation of CSC-like properties, suggesting a potential therapeutic target for overcoming drug resistance in NSCLC.

Topics & Keywords

MicroRNA in disease regulation Cancer-related molecular mechanisms research Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 9, Issue 1, pp. 327-327

DOI: 10.1186/s13287-018-1072-1

Field-Weighted Citation Impact: 4.05