Dissecting the Heterogeneous Cortical Anatomy of Autism Spectrum Disorder Using Normative Models

2018218 citationsJournal Articlehybrid Open Access

Authors

Mariam Zabihi · Radboud University Nijmegen

Marianne Oldehinkel · Radboud University Nijmegen

Thomas Wolfers · Radboud University Nijmegen

Vincent Frouin · Commissariat à l'Énergie Atomique et aux Énergies Alternatives

David Goyard · Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Eva Loth · King's College London

Tony Charman

Abstract

Our results 1) reinforce the notion that individuals with ASD show distinct, highly individualized trajectories of brain development and 2) show that by focusing on common effects (i.e., the "average ASD participant"), the case-control approach disguises considerable interindividual variation crucial for precision medicine.

Topics & Keywords

Autism Spectrum Disorder Research Genetics and Neurodevelopmental Disorders Functional Brain Connectivity Studies

Publication Details

Published in: Biological Psychiatry Cognitive Neuroscience and Neuroimaging

Volume 4, Issue 6, pp. 567-578

DOI: 10.1016/j.bpsc.2018.11.013

Field-Weighted Citation Impact: 9.05

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Dissecting the Heterogeneous Cortical Anatomy of Autism Spectrum Disorder Using Normative Models

Authors

Abstract

Topics & Keywords

Publication Details