Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial

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Authors

Sean P. Polster · University of Utah

Agnieszka Stadnik · National Institute of Neurological Disorders and Stroke

Amy Akers · University of New Mexico

Ying Cao · Angioma Alliance

Gregory A. Christoforidis · Mayo Clinic

Maged D Fam · University of Chicago Medical Center

Kelly D. Flemming

Abstract

With firm mechanistic rationale, rigorous preclinical discoveries, and biomarker validations, the trial shall explore a proof of concept effect of a widely used repurposed drug in stabilizing CAs after a symptomatic hemorrhage. This will be the first clinical trial of a drug aimed at altering rebleeding in CA.

Topics & Keywords

Vascular Malformations Diagnosis and Treatment Intracranial Aneurysms: Treatment and Complications Intracerebral and Subarachnoid Hemorrhage Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurosurgery

Volume 85, Issue 6, pp. 843-853

DOI: 10.1093/neuros/nyy539

Field-Weighted Citation Impact: 5.82