Enantioselective C(sp³)–H Amidation of Thioamides Catalyzed by a Cobalt^III/Chiral Carboxylic Acid Hybrid System

Recent advances in Cp^x M^III catalysis (M=Co, Rh, Ir) have enabled a variety of enantioselective C(sp² )-H functionalization reactions, but enantioselective C(sp³ )-H functionalization is still largely unexplored. We describe an asymmetric C(sp³ )-H amidation of thioamides using an achiral Co^III /chiral carboxylic acid hybrid catalytic system, which provides easy and straightforward access to chiral β-amino thiocarbonyl and β-amino carbonyl building blocks with a quaternary carbon stereocenter.