The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals

2018283 citationsJournal Articlebronze Open Access

Authors

Reisa A. Sperling · Brigham and Women's Hospital

Elizabeth C. Mormino · Harvard University

Aaron P. Schultz · Harvard University

Rebecca A. Betensky · Harvard University

Kathryn V. Papp · Brigham and Women's Hospital

Rebecca E. Amariglio · Brigham and Women's Hospital

Bernard Hanseeuw

Abstract

Our results are consistent with the supposition that both Aβ and tau are necessary for memory decline in the preclinical stages of AD. These findings may be relevant for disambiguating aging and early cognitive manifestations of AD, and to inform secondary prevention trials in preclinical AD. Ann Neurol 2019;00:1-3 ANN NEUROL 2019;85:181-193.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Cognitive Functions and Memory

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 85, Issue 2, pp. 181-193

DOI: 10.1002/ana.25395

Field-Weighted Citation Impact: 17.89