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<b>Introduction:</b> The hemodynamic situation is the main prognostic factor of pulmonary embolism (PE). The fibrinolytic treatment is of choice in patients who are hemodynamically unstable, and who do not have an elevated risk of bleeding. However, in hemodynamically stable patients with data of intermediate risk, fibrinolysis is only recommended as rescue therapy if hemodynamic deterioration occurs. The aim of our study was to analyze the use of fibrinolytics in our center. <b>Material and Methods:</b> Retrospective analysis of the data of patients diagnosed with PE in our center and included prospectively in the RIETE registry from January 2004 to October 2017. Clinical, imaging and laboratory data were collected, as well as the treatment and results. The qualitative variables are expressed as absolute and relative frequency (number and percentage of patients) and continuous variables by mean and standard deviation. For the univariate analysis, the Chi square test or Fisher9s exact test was used for the categorical variables and the student9s t or Mann Whitney9s t for the quantitative ones. <b>Results:</b> 946 subjects were diagnosed with PE, of which 55 (5.81%) received fibrinolytic therapy. In the prognostic stratification of fibrinolyzed patients in our center, 6 (10.9%) were high risk and 49 (89.1%) were hemodynamically stable. <b>Conclusions:</b> The use of fibrinolytic therapy does not always follow the recommendations of clinical practice guidelines. Fibrinolysis was more frequent in the group of hemodynamically stable patients, with a lower overall mortality compared to the group of intermediate risk patients who did not receive fibrinolysis without significant increase in hemorrhagic complications.