Epigenome-wide meta-analysis of DNA methylation and childhood asthma

2018207 citationsReviewhybrid Open Access

Authors

Sarah E. Reese · National Institutes of Health

Cheng‐Jian Xu · University Medical Center Groningen

Herman T. den Dekker · Erasmus MC

Mi Kyeong Lee · National Institutes of Health

Sinjini Sikdar · National Institutes of Health

Carlos Ruiz-Arenas · Universitat Pompeu Fabra

Simon Kebede Merid

Abstract

Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.

Topics & Keywords

Epigenetics and DNA Methylation Asthma and respiratory diseases Neonatal Respiratory Health Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Allergy and Clinical Immunology

Volume 143, Issue 6, pp. 2062-2074

DOI: 10.1016/j.jaci.2018.11.043

Field-Weighted Citation Impact: 8.82