Mechanism of<i>Pseudomonas aeruginosa</i>Small Protease (PASP), a Corneal Virulence Factor

201817 citationsJournal Articlegold Open Access

Authors

Aihua Tang · University of Mississippi Medical Center

Armando R. Caballero · University of Mississippi Medical Center

Mary E. Marquart · University of Mississippi Medical Center

Michael A. Bierdeman · University of Mississippi Medical Center

Richard J. O’Callaghan · University of Mississippi Medical Center

Abstract

PASP is a secreted serine protease that can cleave proteins at arginine or lysine residues and PASP activity requires dimer or larger aggregates to create a functional active site. Most importantly, proteolytic PASP molecules demonstrated highly significant toxicity for the rabbit cornea.

Topics & Keywords

Ocular Infections and Treatments Bacterial biofilms and quorum sensing Ocular Surface and Contact Lens

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 59, Issue 15, pp. 5993-5993

DOI: 10.1167/iovs.18-25834

Field-Weighted Citation Impact: 1.51

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Mechanism of<i>Pseudomonas aeruginosa</i>Small Protease (PASP), a Corneal Virulence Factor

Authors

Abstract

Topics & Keywords

Publication Details