Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma

2018101 citationsJournal Articlegold Open Access

Authors

Huan Lu · Third Affiliated Hospital of Southern Medical University

Dandan Ju · Obstetrics and Gynecology Hospital of Fudan University

Guangdong Yang · Southern Medical University

Linyan Zhu · Southern Medical University

Xiaomei Yang · Shanghai Jiao Tong University

Jun Li · Shanghai Jiao Tong University

Weiwei Song

Abstract

Taken together, we conclude that SMOC-2 might be a novel endometrial cancer stem cell signature gene and therapeutic target for endometrial cancer. FUND: National Natural Science Foundation of China, Scientific and Technological Innovation Act Program of Shanghai Science and Technology Commission, Scientific and Technological Innovation Act Program of Fengxian Science and Technology Commission, Natural Science Foundation of Shanghai.

Topics & Keywords

Cancer Cells and Metastasis Wnt/β-catenin signaling in development and cancer MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EBioMedicine

Volume 40, pp. 276-289

DOI: 10.1016/j.ebiom.2018.12.044

Field-Weighted Citation Impact: 3.49