Genetic Complexity of Mitral Valve Prolapse Revealed by Clinical and Genetic Evaluation of a Large Family.

20174 citationsJournal Article

Authors

Gloria Haskell

Brian C. Jensen · University of North Carolina at Chapel Hill

Cécile Skrzynia · University of North Carolina at Chapel Hill

Thelsa Pulikkotil · Kaiser Permanente

Christian R. Tilley · University of North Carolina at Chapel Hill

Yurong Lu · University of North Carolina at Chapel Hill

Daniel S. Marchuk · University of North Carolina at Chapel Hill

Abstract

While a contributory role for PTPRJ and FLYWCH1 in this family cannot be excluded, the study results underscored the difficulties involved in uncovering the genomic contribution to MVP, even in apparently Mendelian families.

Topics & Keywords

Cardiac Valve Diseases and Treatments Connective tissue disorders research Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 26, Issue 5, pp. 569-580

Field-Weighted Citation Impact: 0.00