Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

2019374 citationsJournal Articlebronze Open Access

Authors

Seth A. Sharp · University of Exeter

Stephen S. Rich · University of Virginia

Andrew R. Wood · University of Exeter

Samuel E. Jones · University of Exeter

Robin N. Beaumont · University of Exeter

Jamie Harrison · University of Exeter

Darius Schneider ·

Abstract

An improved T1D GRS, the T1D GRS2, is highly useful for classifying adult incident diabetes type and improving newborn screening. Given the cost-effectiveness of SNP genotyping, this approach has great clinical and research potential in T1D.

Topics & Keywords

Diabetes and associated disorders Pancreatic function and diabetes Diabetes Management and Research

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Diabetes Care

Volume 42, Issue 2, pp. 200-207

DOI: 10.2337/dc18-1785

Field-Weighted Citation Impact: 24.77