CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

2019651 citationsJournal Articlegreen Open Access

Authors

Robbie G. Majzner · Stanford University

Johanna Theruvath · Stanford University

Anandani Nellan

Sabine Heitzeneder · Stanford University

Yongzhi Cui

Christopher Mount

Skyler P. Rietberg · Stanford University

Miles H. Linde

Peng Xu

Abstract

B7-H3 CAR T cells could represent an exciting therapeutic option for patients with certain lethal relapsed or refractory pediatric malignancies, and should be tested in carefully designed clinical trials.

Topics & Keywords

CAR-T cell therapy research Nanowire Synthesis and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 25, Issue 8, pp. 2560-2574

DOI: 10.1158/1078-0432.ccr-18-0432

Field-Weighted Citation Impact: 29.91