Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo

2019280 citationsJournal Articlebronze Open Access

Authors

Shengnan Wu · Georgia State University

Qiulun Lu · Georgia State University

Ye Ding · Georgia State University

Yin Wu · Georgia State University

Yu Qiu · Georgia State University

Pei Wang · MRC Mitochondrial Biology Unit

Xiaoxiang Mao ·

Abstract

We conclude that diabetes mellitus suppresses AMP-activated protein kinase, initiating Fundc1-mediated MAM formation, mitochondrial dysfunction, and cardiomyopathy, suggesting that AMP-activated protein kinase-induced Fundc1 suppression is a valid target to treat diabetic cardiomyopathy.

Topics & Keywords

Mitochondrial Function and Pathology Autophagy in Disease and Therapy Endoplasmic Reticulum Stress and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 139, Issue 16, pp. 1913-1936

DOI: 10.1161/circulationaha.118.033552

Field-Weighted Citation Impact: 9.68