Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

2019457 citationsJournal Articlegold Open Access

Authors

Xing Qin · Shanghai Jiao Tong University

Haiyan Guo · Shanghai Ninth People's Hospital

Xiaoning Wang · Shanghai Ninth People's Hospital

Xueqin Zhu · Shanghai Ninth People's Hospital

Ming Yan · Shanghai Jiao Tong University

Xu Wang · Shanghai Ninth People's Hospital

Qin Xu ·

Abstract

The present study finds that CAF-derived exosomal miR-196a confers cisplatin resistance in HNC by targeting CDKN1B and ING5, indicating miR-196a may serve as a promising predictor of and potential therapeutic target for cisplatin resistance in HNC.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation Circular RNAs in diseases

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Genome biology

Volume 20, Issue 1, pp. 12-12

DOI: 10.1186/s13059-018-1604-0

Field-Weighted Citation Impact: 26.63