Elevated expression of GNAS promotes breast cancer cell proliferation and migration via the PI3K/AKT/Snail1/E-cadherin axis

201976 citationsJournal Articlehybrid Open Access

Authors

Xiaosong Jin · First Affiliated Hospital of Chongqing Medical University

Li Zhu · Second People’s Hospital of Yibin

Zhuhong Cui · Second People’s Hospital of Yibin

Jing Tang · Second People’s Hospital of Yibin

Mingjun Xie · Second People’s Hospital of Yibin

Guosheng Ren · First Affiliated Hospital of Chongqing Medical University

Abstract

The data suggested that GNAS promoted breast cancer cell proliferation and migration (EMT) through the PI3K/AKT/Snail1/E-cadherin signaling pathway. These findings also indicate that GNAS can serve as a potential prognostic indicator and novel therapeutic target in breast cancer.

Topics & Keywords

Cancer Genomics and Diagnostics Cancer Cells and Metastasis PI3K/AKT/mTOR signaling in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical & Translational Oncology

Volume 21, Issue 9, pp. 1207-1219

DOI: 10.1007/s12094-019-02042-w

Field-Weighted Citation Impact: 2.68