Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing <scp>NLRP</scp>3 inflammasomes and <scp>TLR</scp>4/<scp>NF</scp>‐κB signaling pathway

2019363 citationsJournal Articlegold Open Access

Authors

Xin Jin · China Medical University

Ming‐Yan Liu · China Medical University

Dongfang Zhang · China Medical University

Xin Zhong · China Medical University

Ke Du · China Medical University

Ping Qian · China Medical University

Weifan Yao ·

Abstract

Overall, the results of the present study indicated that BAI is a promising neuroprotective compound for use in the prevention and treatment of microglia-mediated neuroinflammation during AD progression.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Inflammasome and immune disorders Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: CNS Neuroscience & Therapeutics

Volume 25, Issue 5, pp. 575-590

DOI: 10.1111/cns.13086

Field-Weighted Citation Impact: 14.59