Mutant <i>KCNJ3</i> and <i>KCNJ5</i> Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation

The I_KACh channel is associated with the pathophysiology of bradyarrhythmia and atrial fibrillation, and the mutant I_KACh channel ( KCNJ3 p.N83H) can be effectively inhibited by NIP-151, a selective I_KACh channel blocker. Thus, the I_KACh channel might be considered to be a suitable pharmacological target for patients who have bradyarrhythmia with a gain-of-function mutation in the I_KACh channel.