A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects

2019219 citationsJournal Articlehybrid Open Access

Authors

Himanshu Tyagi · National Hospital for Neurology and Neurosurgery

Annemieke M. Apergis-Schoute · University of Cambridge

Harith Akram · National Hospital for Neurology and Neurosurgery

Thomas Foltynie · National Hospital for Neurology and Neurosurgery

Patricia Limousin · National Hospital for Neurology and Neurosurgery

Lynne M. Drummond · South West London and St George's Mental Health NHS Trust

Abstract

Both the VC/VS and amSTN are effective targets for severe treatment-refractory OCD. Differential improvements in mood and cognitive flexibility and their associated connectivity suggest that DBS at these sites modulates distinct brain networks.

Topics & Keywords

Obsessive-Compulsive Spectrum Disorders Transcranial Magnetic Stimulation Studies Neurological disorders and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Biological Psychiatry

Volume 85, Issue 9, pp. 726-734

DOI: 10.1016/j.biopsych.2019.01.017

Field-Weighted Citation Impact: 33.29