Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease

2019337 citationsJournal Articlebronze Open Access

Authors

Constant V.M. Verschuur · Amsterdam Neuroscience

Sven R. Suwijn · Amsterdam Neuroscience

Judith A. Boel · Amsterdam Neuroscience

Bart Post · Radboud University Medical Center

Bas R. Bloem · Radboud University Medical Center

Johannes J. van Hilten · Leiden University Medical Center

Teus van Laar

Abstract

Among patients with early Parkinson's disease who were evaluated over the course of 80 weeks, treatment with levodopa in combination with carbidopa had no disease-modifying effect. (Funded by the Netherlands Organization for Health Research and Development and others; LEAP Current Controlled Trials number, ISRCTN30518857 .).

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Autism Spectrum Disorder Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 380, Issue 4, pp. 315-324

DOI: 10.1056/nejmoa1809983

Field-Weighted Citation Impact: 31.22