A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis

2019133 citationsJournal Articlebronze Open Access

Authors

Zhijun Zhou · Sun Yat-sen University

Guanggai Xia · Sun Yat-sen University

Zhen Xiang · Sun Yat-sen University

Mingyang Liu · University of Oklahoma Health Sciences Center

Zhewei Wei · Sun Yat-sen University

Jie Yan · University of Oklahoma Health Sciences Center

Wei Chen ·

Abstract

Our study suggested a previously uncharacterized mechanism through which gastric cancer cells interact with macrophages to promote tumor growth and metastasis, suggesting that CXCR2 may serve as a promising therapeutic target to treat gastric cancer.

Topics & Keywords

Immune cells in cancer Chemokine receptors and signaling Immunotherapy and Immune Responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 25, Issue 11, pp. 3317-3328

DOI: 10.1158/1078-0432.ccr-18-3567

Field-Weighted Citation Impact: 6.21