Continuation of Statin Therapy in Patients with Presumed Infection: A Randomized Controlled Trial

2010116 citationsJournal Article

Authors

Peter Krüger · Society of Critical Care Medicine

Meg Harward · Princess Alexandra Hospital

Mark Jones

Chris Joyce · Society of Critical Care Medicine

Karam Kostner · Mater Private Hospital

Michael S. Roberts · The University of Queensland

Balasubramanian Venkatesh · Wesley Hospital

Abstract

This study does not support a beneficial role of continuing preexisting statin therapy on sepsis and inflammatory parameters. Cessation of established statin therapy was not associated with an inflammatory rebound. Clinical trial registered at the Australian New Zealand Clinical Trials Registry (ACTRN 12605000756628).

Topics & Keywords

Lipoproteins and Cardiovascular Health Sepsis Diagnosis and Treatment Vitamin K Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 183, Issue 6, pp. 774-781

DOI: 10.1164/rccm.201006-0955oc

Field-Weighted Citation Impact: 11.86