Randomized, double‐blind, placebo‐controlled study of interferon‐<i>γ</i> 1b in Friedreich Ataxia

201943 citationsJournal Articlegold Open Access

Authors

David R. Lynch · Children's Hospital of Philadelphia

Lauren Hauser · Children's Hospital of Philadelphia

Ashley McCormick · Children's Hospital of Philadelphia

McKenzie Wells · Children's Hospital of Philadelphia

Yi Dong · Children's Hospital of Philadelphia

Shana E. McCormack · Children's Hospital of Philadelphia

Kim Schadt

Abstract

This study provides no direct evidence for a beneficial effect of IFN-<i>γ</i>1b in FRDA. The modest stabilization compared to natural history data leaves open the possibility that longer studies may demonstrate benefit.

Topics & Keywords

Genetic Neurodegenerative Diseases Mitochondrial Function and Pathology Parkinson's Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Clinical and Translational Neurology

Volume 6, Issue 3, pp. 546-553

DOI: 10.1002/acn3.731

Field-Weighted Citation Impact: 2.50