Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor–Positive Metastatic Breast Cancer

2019445 citationsJournal Articlehybrid Open Access

Authors

Nicholas C. Turner · Institute of Cancer Research

Yuan Liu · Pfizer (United States)

Zhou Zhu · Pfizer (United States)

Sherene Loi · Peter MacCallum Cancer Centre

Marco Colleoni · Istituti di Ricovero e Cura a Carattere Scientifico

Sibylle Loibl · German Breast group

Angela DeMichele

Abstract

Addition of palbociclib to fulvestrant demonstrated efficacy in all biomarker groups, although high <i>CCNE1</i> mRNA expression was associated with relative resistance to palbociclib.

Topics & Keywords

Advanced Breast Cancer Therapies Cancer-related Molecular Pathways HER2/EGFR in Cancer Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 37, Issue 14, pp. 1169-1178

DOI: 10.1200/jco.18.00925

Field-Weighted Citation Impact: 33.70