Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca <sup>2+</sup> -ATPase in Heart Failure

2019129 citationsJournal Articlebronze Open Access

Authors

Przemek A. Gorski · Icahn School of Medicine at Mount Sinai

Seung Pil Jang · Gwangju Institute of Science and Technology

Dongtak Jeong · Icahn School of Medicine at Mount Sinai

Ah Young Lee · Icahn School of Medicine at Mount Sinai

Philyoung Lee · Icahn School of Medicine at Mount Sinai

Jae Gyun Oh · Icahn School of Medicine at Mount Sinai

Vadim Chepurko

Abstract

These results indicate that acetylation/deacetylation at K492, which is regulated by SIRT1 and p300, is critical for the regulation of SERCA2a activity in hearts. Pharmacological activation of SIRT1 can restore SERCA2a activity through deacetylation at K492. These findings might provide a novel strategy for the treatment of heart failure.

Topics & Keywords

Sirtuins and Resveratrol in Medicine Adenosine and Purinergic Signaling Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 124, Issue 9, pp. e63-e80

DOI: 10.1161/circresaha.118.313865

Field-Weighted Citation Impact: 8.18