A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis

2019463 citationsJournal Articlegold Open Access

Authors

Yufeng Wang · First Affiliated Hospital of Xi'an Jiaotong University

Liu Yang · Zhejiang Provincial People's Hospital

Tianxiang Chen · First Affiliated Hospital of Xi'an Jiaotong University

Xin Liu · Zhejiang Provincial People's Hospital

Yang Guo · Bengbu Medical College

Qiaojuan Zhu · Zhejiang Chinese Medical University

Xiangmin Tong

Abstract

Our results recognized MCM3AP-AS1 as a novel oncogenic lncRNA, which indicated poor clinical outcomes in patients with HCC. MCM3AP-AS1 exerted an oncogenic role in HCC via targeting miR-194-5p and subsequently promoted FOXA1 expression. Our findings suggested that MCM3AP-AS1 could be a potential prognostic biomarker and therapeutic target for HCC.

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Publication Details

Published in: Molecular Cancer

Volume 18, Issue 1, pp. 28-28

DOI: 10.1186/s12943-019-0957-7

Field-Weighted Citation Impact: 30.09

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A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis

Authors

Abstract

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Publication Details