PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease

2019135 citationsReview

Authors

Abstract

This review indicates that PI3K/Ak-Nrf2 may play an important role in COPD inflammation and macrolides may reduce lung and systemic inflammation of COPD by regulating PI3K/Akt-Nrf2 pathway. However, many crucial and essential questions remain to be answered. Further understanding of the mechanisms of macrolide efficacy and PI3K/Akt-Nrf2-mediated inflammatory responses may provide a new clue for exploring COPD treatment in the future.

Topics & Keywords

Chronic Obstructive Pulmonary Disease (COPD) Research Pediatric health and respiratory diseases Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Current Drug Metabolism

Volume 20, Issue 4, pp. 301-304

DOI: 10.2174/1389200220666190227224748

Field-Weighted Citation Impact: 8.34