Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure

201927 citationsJournal Articlegold Open Access

Authors

Chen Gao · University of California, Los Angeles

Shuxun Ren · University of California, Los Angeles

Junyi Yu · Army Medical University

Ulysis Baal · University of California, Los Angeles

Dung Thai · Juvaris BioTherapeutics (United States)

John Lu · Juvaris BioTherapeutics (United States)

Chunyu Zeng

Abstract

Systemic treatment of an antibody-based glucagon receptor antagonist confers cardioprotection against myocardial infarction and post-myocardial infarction remodeling in mice. Systemic treatment of glucagon receptor antagonist prevents pressure overload induced cardiac remodeling and dysfunction in mice. Glucagon receptor antagonist treatment attenuates the pathological progression of heart failure induced by pressure overload in mice. Long-term suppression of glucagon signaling is potentially an effective therapy for heart failure with different etiologies independent of metabolic disorders.

Topics & Keywords

Diabetes Treatment and Management Receptor Mechanisms and Signaling Heart Failure Treatment and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JACC Basic to Translational Science

Volume 4, Issue 2, pp. 161-172

DOI: 10.1016/j.jacbts.2018.11.001

Field-Weighted Citation Impact: 1.75