IGF-axis confers transformation and regeneration of fallopian tube fimbria epithelium upon ovulation

201954 citationsJournal Articlegold Open Access

Authors

Che‐Fang Hsu · National Dong Hwa University

Hsuan-Shun Huang · Buddhist Tzu Chi General Hospital

Pao‐Chu Chen · Buddhist Tzu Chi General Hospital

Dah‐Ching Ding · Buddhist Tzu Chi General Hospital

Abstract

This study revealed that the FF-IGF axis functions to regenerate tissue damage after ovulation and promote the transformation of fimbrial epithelial cells that have been initiated by p53- and Rb-pathway disruptions. FUND: The study was supported by grants of the Ministry of Science and Technology, Taiwan (MOST 106-2314-B-303-001-MY2; MOST 105-2314-B-303-017-MY2; MOST 107-2314-B-303-013-MY3), and Buddhist Tzu Chi General Hospital, Taiwan (TCMMP104-04-01).

Topics & Keywords

Ovarian cancer diagnosis and treatment Reproductive Biology and Fertility Growth Hormone and Insulin-like Growth Factors

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: EBioMedicine

Volume 41, pp. 597-609

DOI: 10.1016/j.ebiom.2019.01.061

Field-Weighted Citation Impact: 6.37