STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

2019231 citationsJournal Articlegold Open Access

Authors

Qiongyuan Hu · Nanjing General Hospital of Nanjing Military Command

Huajian Ren · Nanjing General Hospital of Nanjing Military Command

Guanwei Li · Guangzhou First People's Hospital

Dingyu Wang · Model Animal Research Center

Quan Zhou · Nanjing Medical University

Jie Wu · Nanjing General Hospital of Nanjing Military Command

Jiashuo Zheng

Abstract

Our results indicate that the STING signaling pathway can contribute to lethal sepsis by promoting IEC apoptosis and through disrupting the intestinal barrier. Our findings suggest that regulation of the mtDNA-STING pathway may be a promising therapeutic strategy to promote mucosal healing and protect the intestinal barrier in septic patients. FUND: National Natural Science Foundation of China.

Topics & Keywords

interferon and immune responses Inflammasome and immune disorders Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EBioMedicine

Volume 41, pp. 497-508

DOI: 10.1016/j.ebiom.2019.02.055

Field-Weighted Citation Impact: 8.39