KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical AD

201964 citationsJournal Articlebronze Open Access

Authors

Claire M Erickson · Alzheimer's Association

Stephanie A. Schultz · Alzheimer's Association

Jennifer M. Oh · Alzheimer's Association

Burcu F. Darst · Alzheimer's Association

Yue Ma · Alzheimer's Association

Derek Norton · Alzheimer's Association

Tobey J. Betthauser ·

Abstract

In a cohort of at-risk late-middle-aged adults, KL-VS heterozygosity was associated with an abatement of APOE4-associated Aβ aggregation, suggesting KL-VS heterozygosity confers protections against APOE4-linked pathways to disease onset in AD.

Topics & Keywords

Alzheimer's disease research and treatments Amyloidosis: Diagnosis, Treatment, Outcomes Parathyroid Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 92, Issue 16, pp. e1878-e1889

DOI: 10.1212/wnl.0000000000007323

Field-Weighted Citation Impact: 4.70

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<i>KLOTHO</i> heterozygosity attenuates <i>APOE4</i> -related amyloid burden in preclinical AD

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details