A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis

2019105 citationsJournal Article

Authors

Li Fan · Shanxi University of Traditional Chinese Medicine

Xiaodong Wang · Taiyuan Central Hospital

Jinyin Ge · Shanxi University

Feng Li · Canadian Sleep Society

Xiao Wang · Shanxi University of Traditional Chinese Medicine

Juanjuan Wang · Shanxi University

Shaomin Shuang ·

Abstract

A lysosome-targeting and polarity-specific fluorescent probe CPM has been rationally designed for cancer diagnosis and imaging. We have successfully shown that lysosome polarity may serve as an ubiquitious marker for cancer detection. The potential of CPM for cancer diagnosis has also been demonstrated at the levels of live cells, organs, whole animal, and clinical patient tissue samples.

Topics & Keywords

Advanced biosensing and bioanalysis techniques Click Chemistry and Applications Molecular Sensors and Ion Detection

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Chemical Communications

Volume 55, Issue 32, pp. 4703-4706

DOI: 10.1039/c9cc00962k

Field-Weighted Citation Impact: 4.94