Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium

2019155 citationsJournal Articlehybrid Open Access

Authors

B.T. Li · Memorial Sloan Kettering Cancer Center

Filip Jankú

B. Jung · Illumina (United States)

C. Hou · Illumina (United States)

Kiran Madwani

Ryan S. Alden · Dana-Farber Cancer Institute

Pedram Razavi · Memorial Sloan Kettering Cancer Center

Jorge S. Reis‐Filho

Abstract

Ultra-deep plasma NGS with clonal hematopoiesis filtering resulted in de novo detection of targetable oncogenic drivers and resistance mechanisms in patients with NSCLC, including when tissue biopsy was inadequate for genotyping.

Topics & Keywords

Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations Pancreatic and Hepatic Oncology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Oncology

Volume 30, Issue 4, pp. 597-603

DOI: 10.1093/annonc/mdz046

Field-Weighted Citation Impact: 7.72