Randomized, Double‐Blind, Placebo‐Controlled Trial of Intraarticular Trans <i>‐</i> Capsaicin for Pain Associated With Osteoarthritis of the Knee

In this study, CNTX-4975 provided dose-dependent improvement in knee OA-associated pain. CNTX-4975 1.0 mg produced a significant decrease in OA knee pain through 24 weeks; CNTX-4975 0.5 mg significantly improved pain at 12 weeks, but the effect was not evident at 24 weeks.