Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

2019220 citationsJournal Articlegold Open Access

Authors

Chang-xiong Zhang · Air Force Medical University

Ying Cheng · Air Force Medical University

Daozhou Liu · Air Force Medical University

Miao Liu · Air Force Medical University

Han Cui · Air Force Medical University

Bang‐Le Zhang · Air Force Medical University

Qibing Mei ·

Abstract

CsA@PLGA-PEG-SS31 exhibited significant cardioprotective effects against MI/RI in rats hearts through protecting mitochondrial integrity, decreasing apoptosis of cardiomyocytes and myocardial infract area. Thus, CsA@PLGA-PEG-SS31 offered a promising therapeutic method for patients with acute myocardial infarction.

Topics & Keywords

Cardiac Ischemia and Reperfusion RNA Interference and Gene Delivery Fuel Cells and Related Materials

Publication Details

Published in: Journal of Nanobiotechnology

Volume 17, Issue 1, pp. 18-18

DOI: 10.1186/s12951-019-0451-9

Field-Weighted Citation Impact: 10.63

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Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

Authors

Abstract

Topics & Keywords

Publication Details