Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

201980 citationsJournal Articlegold Open Access

Authors

Shraddha Sharma · Roswell Park Comprehensive Cancer Center

Jianmin Wang · Roswell Park Comprehensive Cancer Center

Emad Alqassim · Roswell Park Comprehensive Cancer Center

Scott Portwood · Roswell Park Comprehensive Cancer Center

Eduardo Cortes Gomez · Roswell Park Comprehensive Cancer Center

Orla Maguire · Roswell Park Comprehensive Cancer Center

Per Basse

Abstract

APOBEC3G is an endogenous RNA editing enzyme in primary natural killer cells and lymphoma cell lines. This RNA editing is induced by cellular crowding and mitochondrial respiratory inhibition to promote adaptation to hypoxic stress.

Topics & Keywords

RNA regulation and disease RNA Research and Splicing Cytomegalovirus and herpesvirus research

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Genome biology

Volume 20, Issue 1, pp. 37-37

DOI: 10.1186/s13059-019-1651-1

Field-Weighted Citation Impact: 4.04