Complement-mediated Damage to the Glycocalyx Plays a Role in Renal Ischemia-reperfusion Injury in Mice

201934 citationsJournal Articlegold Open Access

Authors

Anjan K. Bongoni · St Vincent's Hospital

Bo Lü · St Vincent's Hospital

Jennifer L. McRae · St Vincent's Hospital

Evelyn Salvaris · St Vincent's Hospital

Erik J. M. Toonen · Hycult Biotech (Netherlands)

Ingela B. Vikstrom · CSL (Australia)

Adriana Baz Morelli ·

Abstract

Together, our data confirm that the terminal pathway of complement activation plays a key role in renal IRI and demonstrate that the mechanism of injury involves shedding of the glycocalyx.

Topics & Keywords

Trauma, Hemostasis, Coagulopathy, Resuscitation Acute Kidney Injury Research Blood donation and transfusion practices

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Transplantation Direct

Volume 5, Issue 4, pp. e341-e341

DOI: 10.1097/txd.0000000000000881

Field-Weighted Citation Impact: 3.19