A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer

201959 citationsJournal Article

Authors

Robert Piskol

Ling Huw · Biomarker Technologies (China)

Ismail Sergin · Intermolecular (United States)

Christiaan Kljin

Zora Modrušan · Intermolecular (United States)

Doris Kim · Biomarker Technologies (China)

Noelyn M. Kljavin · Intermolecular (United States)

Rachel Tam

Abstract

We describe the utility of a NanoString panel for CMS classification of FFPE clinical samples. Our work reveals the impact of intrinsic and extrinsic factors on colorectal cancer heterogeneity during disease progression.

Topics & Keywords

Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer Colorectal Cancer Surgical Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 25, Issue 14, pp. 4431-4442

DOI: 10.1158/1078-0432.ccr-18-3032

Field-Weighted Citation Impact: 4.03