Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction

201960 citationsJournal Article

Authors

Julian Friebel · Charité - Universitätsmedizin Berlin

Alice Weithäuser · Charité - Universitätsmedizin Berlin

Marco Witkowski · Charité - Universitätsmedizin Berlin

Bernhard H. Rauch · German Centre for Cardiovascular Research

Konstantinos Savvatis · William Harvey Research Institute

Andrea Dörner · Charité - Universitätsmedizin Berlin

Termeh Tabaraie

Abstract

Protease-activated receptor 2 is an important regulator of profibrotic PAR1 and TGF-β signalling in the heart. Modulation of the FXa/FIIa-PAR1/PAR2/TGF-β-axis might be a promising therapeutic approach to reduce HFpEF.

Topics & Keywords

Blood Coagulation and Thrombosis Mechanisms Heart Failure Treatment and Management Atrial Fibrillation Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Heart Journal

Volume 40, Issue 40, pp. 3318-3332

DOI: 10.1093/eurheartj/ehz117

Field-Weighted Citation Impact: 5.22