CGRP and the Trigeminal System in Migraine

2019473 citationsReviewhybrid Open Access

Authors

Smriti Iyengar · Eli Lilly (United States)

Kirk W. Johnson · Eli Lilly (United States)

Michael H. Ossipov · Syneos Health (United States)

Sheena K. Aurora · Eli Lilly (United States)

Abstract

CGRP plays an essential role in the pathophysiology of migraine. Treatments that interfere with the functioning of CGRP in the peripheral trigeminal system are effective against migraine. Blocking sensitization of the trigeminal nerve by attenuating CGRP activity in the periphery may be sufficient to block a migraine attack. Additionally, the potential exists that this therapeutic strategy may also alleviate cluster headache as well.

Topics & Keywords

Migraine and Headache Studies Trigeminal Neuralgia and Treatments Vestibular and auditory disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Headache The Journal of Head and Face Pain

Volume 59, Issue 5, pp. 659-681

DOI: 10.1111/head.13529

Field-Weighted Citation Impact: 28.27